600 MHz Protonen Nitrogen HMBC

600 MHz: ¹H-¹⁵N-HMBC

¹H-¹⁵N-HMBC is basically the same as the classical HMBC (proton-carbon correlation) experiment, but as a result you obtain the ¹H-¹⁵N-correlation.

In contrast to a ¹⁵N-NMR spectrum it is much moresensitive. Thus you need less time for a measurement. In one example (molecular weight 100 g/mol, concentration 30 mg/ml) it was possible to optai a good quality ¹H-¹⁵N-HMBC-spectrum within 30 min. In order to obtain a ¹⁵N-NMR spectrum under the same conditionsone would need several hours.

In addition the ¹H-¹⁵N-HMBC-spectrum has the advantage, that the correlation gives you additional information for structure elucidation.

Thus normally one should prefer an ¹H-¹⁵N-HMBC-spectrum over a ¹⁵N-NMR spectrum.

Hear you will find genearal Information on ¹⁵N-NMR:

1) Chemgapedia

2) Science and Fun